Improved acetylating radioenzymatic assay of amikacin, tobramycin, and sisomicin in serum.
نویسندگان
چکیده
The acetylating radioenzymatic assay of aminoglycosides was modified by using [(3)H]acetyl coenzyme A as cosubstrate. This modification reduces the cost of the method by at least one-half without sacrificing rapidity or accuracy.
منابع مشابه
Serum standards for the bioassay of aminoglycosides in cerebrospinal fluid.
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The in vitro activity of the aminoglycoside antibiotics tobramycin, sisomicin, amikacin, gentamicin, and netilmicin (SCH 20569) were compared against 26 gentamicin-resistant isolates of Pseudomonas aeruginosa cultured from hospitalized children. Tobramycin had the greatest activity on a weight basis, followed by sisomicin, gentamicin, amikacin, and netilmicin. All isolates were resistant to ach...
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ورودعنوان ژورنال:
- Antimicrobial agents and chemotherapy
دوره 7 3 شماره
صفحات -
تاریخ انتشار 1975